Calibration of an insulin pump by optical methods
Calibration of an insulin pump by optical methods
Índice
The objective of this work is to compare the results of the calibration of an insulin pump using two optical methods developed at the Volume Laboratory of the Portuguese Institute for Quality (LVC/IPQ), under the EMPIR project MeDD II – Metrology for Drug Delivery, in a partnership with the Machine Design Group of the Department of Mechanical and Industrial Engineering of NOVA School of Science & Technology. The first being the front track method, which measures the displacement of the meniscus of a liquid (liquid/air interface) inside a capillary tube, over time. The second method is the drop method, which measures the volume growth of a drop over time. Both these methods use a high-resolution camera to capture images and a software to process the acquired data and determine the flow rate. The insulin pump was calibrated at different flow rates (0.25 μL/h, 1 μL/h, 3 μL/h, 6 μL/h, and 10 μL/h). An internal comparison was made with the gravimetric method. The results obtained reveal that the tested insulin pump operates with a non-continuous delivery of fluid.
Joana Afonso is currently doing her thesis to obtain a master’s degree in Mechanical Engineering from the NOVA School of Science and Technology – Nova University of Lisbon – Portugal.
Miguel Álvares holds a MSc degree in Mechanical Engineering from the NOVA School of Science and Technology – Nova University of Lisbon – Portugal.
Elsa Batista holds a master’s degree in Analytical Chemistry from the NOVA School of Science and Technology – Nova University of Lisbon – Portugal in 2007 and has a degree in Applied Chemistry from the NOVA School of Science and Technology – Nova University of Lisbon – Portugal in 1999. Since 1999, she has worked at the Laboratório de Volume of Instituto Português da Qualidade as a superior technician and laboratory manager. She is the contact person and head of the volume subgroup of the EURAMET flow technical committee.
Andreia Furtado is a senior metrologist in the field of liquids’ properties working at IPQ since 2006. She is the head of the Laboratory of the Properties of Liquids since 2013 and hold a PhD degree in Science and Materials Engineering Specialty in Materials Science, from NOVA School of Science and Technology, since 2019.
Rui F. Martins holds a PhD and a MSc degree in Mechanical Engineering from Instituto Superior Técnico since 2005 and 1999, respectively. Between 1991 and 1996, he graduated in Mechanical Engineering, also at Instituto Superior Técnico. He is teaching and doing research at Nova School of Science and Technology, The New University of Lisbon, since 1999. He is Associate Professor and Coordinator of the Mechanical Engineering Integrated Master and of the new Master in Mechanical Engineering at FCT NOVA. He is also a member of the Executive Committee of DEMI and of UNIDEMI – NOVA Research & Development Unit for Mechanical and Industrial Engineering.
Isabel Godinho holds a PhD in Physics from the Faculty of Sciences of the university of Lisboa since 2011 and a degree in Physics from the same University since 1991. She is presently Director of the Metrology Department of IPQ and is Responsible for the national metrology system, in scientific applied and legal metrology since 2015. In 1991, she joined the Laboratório de Medidas Elétricas of Laboratório Nacional de Engenharia e Tecnologia Industrial (LNETI), as a Designated Institute, within the scope of the Sistema Português da Qualidade (SPQ), as the national laboratory for electrical quantities.
Alvares, M., (2020) Implementação de um sistema de medição de microcaudais com recurso a métodos óticos, (Master Thesis in Mechanical Engineering, FCT/UNL)
Batista E., Almeida N., Godinho I., Filipe E., (2015), Uncertainty Calculation in Gravimetric Micro-flow Measurements, Advanced Mathematical and Computational Tools in Metrology and Testing X, London: World Scientific, 86:98–104
Batista, E., Sousa, J. A., Martins, R., (2019), Calibration of insulin pumps, Journal of Diabetes and Treatment, 4; 03
Batista, E., Furtado, A., Ferreira, M. C., Godinho, I., Alvares, M., Afonso, J., Martins, R., (2021), Uncertainty calculations in optical methods used for micro flow measurement”, Measurement: Sensors, 18, 100155
Bissig, H., Petter, H.T., Lucas, P., Batista, E. et al. (2015), Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle, Biomedical Engineering, 60 (4); 301-316
Dumont-Fillon, D. Tahriou, H. Conan, C. and Chappel E. (2014), Insulin micropump with embedded pressure sensors for failure detection and delivery of accurate monitoring, Micromachines, vol. 5, no. 4, pp. 1161–1172
Ogheard, F., Cassette, P. and Boudaoud, A. (2019), Development of an optical measurement method for “sampled” micro-volumes and nano-flow rates, 18th International Flow Measurement Conference, Lisbon.
IEC 60601-2-24:2012, Medical electrical equipment – Part 2-24: Particular requirements for the basic safety and essential performance of infusion pumps and controllers.
JCGM 100:2008, Evaluation of measurement data – Guide to expression of uncertainty in measurement (1sted).
Thurow, K., Krüger, T., and Stoll, N., (2009), “An optical approach for the determination of droplet volumes in nanodispensing”, Journal of Automated Methods and Management in Chemistry, 2009,198732
NP EN ISO 4787 (2011)- Laboratory glassware – Volumetric glassware – Methods for use and testing of capacity.
Wang, B., Demuran A., Gyuricsko E., Hu, H., (2011), An experimental study of pulse micro-flows pertinent to continuous subcutaneous insulin infusion therapy. Exp. Fluids, 51: 65-74.
Calibration, gravimetry, insulin pump, optical method
